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Systems Genetics: from man to microbe, from genotype to phenotype

NBIC
Date:
29 Sep 2011 to 30 Sep 2011
Location:
Groningen, the Netherlands

The availability of complete genome sequences from man and a wide range of other species, and the development of high-throughput technologies have led to the accumulation of biological data at an unprecedented scale. These data are different in nature as they come from various sources and they provide detailed information on the individual components of living cells. However, ample experimental and theoretical evidence indicates that extensive knowledge about the individual components is insufficient to describe the operation of complex cellular systems as a whole. Hence, a central challenge for biology and medicine is to reach a much deeper understanding of the operation of whole cells and cellular assemblies. The complex dynamic behavior of these biological systems is sustained by complex networks of interactions between the individual components. Thus, biological systems cannot be understood intuitively, and theory-based approaches are necessary to unravel this complexity. This insight has led to the emergence of Systems Biology, a holistic approach that is based on the view that biological systems are composed of two types of information: genes, encoding proteins that form the molecular machines that execute the functions of life, and networks of regulatory interactions that control the hierarchical flow of information from DNA to mRNA to proteins to molecular machines to metabolites and, ultimately, to phenotype.

The present symposium “Systems Genetics: from man to microbe, from genotype to phenotype” focuses attention on the genetic aspects in Systems Biology. It brings together leading experts in the field, who will present key-note lectures and, in addition, will attend master classes in which they will share their experience with PhD students and post-doctoral researchers.

Confirmed key-note speakers include:

  • Jun Wang (BGI, China) Sequencing, Sequencing and Sequencing
  • Matthias Heinemann (RUG, Netherlands) Stochasticity-induced phenotypic heterogeneity of clonal bacteria
  • Timothy J. Aitman (Imperial College, England) Whole genomes and epigenomes in the dissection of complex traits
  • Henk Stunnenberg (NCMLS, Netherlands) The BLUEPRINT of hematopoiesis: deregulation of the epigenome by oncofusion proteins in AML
  • Uwe Völker (University Greifswald,Deutschland) Integrated OMICs studies in the characterization of host pathogen interactions
  • Bas van Steensel (NKI, Netherlands) Chromatin domain organization of eukaryotic Genomes
  • Peter Lansdorp (Eriba Institute, Netherlands) Telomeres: from genes to patients
  • Alan D Attie (UW Madison, United States) Genetic Deconstruction of Type 2 Diabetes

For further information and registration see www.systemsgenetics.nl

(Deadline for Posters and Abstracts is July 15th 2011)

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