Post-Doc in Computational and Systems Biology

Added on Jan 12, 2010

Employer description

DynamiX postdoc
The EPFL Laboratory of Computational Systems Biology and the Bioinformatics & Biostatistics Core Facility have an opening for a Post-Doctoral Position in Computational and Systems Biology. More information about the empoyers can be found on their websites: 

Job description

The position is funded through the SystemsX.ch DynamiX project “A Systems Approach to the Yeast Transcriptional Regulatory Network”. The DynamiX project is a collaborative project that involving the Maerkl (EPFL), Shore (U Geneva), Unser (EPFL) and Naef (EPFL) labs.

The specific project involves studying the transcriptional regulation of ribosome biogenesis in the yeast Saccharomyces cerevisiae and the role of chromatin structure in this process. The Shore and Maerkl labs have generated a large body of data, e.g. ChIP-seq and in vitro binding energy measurements for the major transcription factors involved in ribosome biogenesis, which will be analyzed and modeled in combination with publicly available data such as nucleosome position maps. Specifically, the candidate will apply computational tools to combine these data and construct a computational model of the gene regulation network based on biophysical principles. Computational prediction should suggest new experiments, such as the design of synthetic promoter constructs to be tested directly in fluorescent reporter assays. 

The successful candidate will develop research activities pertaining to:

  • Analysis of chromatin immunoprecipitation data from ultra high-throughput sequencing
  • Integration of public datasets and designing relevant comparative studies
  • Biophysical modelling of transcription regulatory networks
  • Quantification of time-lapse imaging data

Job requirements

Computational biology with strong background in transcription regulation, genomics, signal processing, and systems biology. Ph.D. in bioinformatics, computational biology, applied mathematics, physics, computer science, molecular biology or an equivalent discipline.

Job benefits

Contract will be initially for one year, renewable. Salary will be commensurate with qualifications and experience. EPFL is an equal opportunity employer. Starting date: approx. 1st March 2010, position is available immediately.

Apply information

Outstanding and highly motivated individuals are welcome to apply. Please send a full CV, a statement of interest and names of two references by mail or E-mail to: 

For further information, please also contact Prof. Félix Naef or Dr. Jacques Rougemont.

Starting date: approx. 1st March 2010, position is available immediately.

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