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Recon 2: Metabolic reconstruction by consensus


01 Mar 2013

Just as all roads lead to Rome, all biological pathways point the focus on metabolism. Studying human health and disease requires thorough understanding of metabolism and as a result, numerous efforts have been dedicated towards metabolic reconstructions that bring together biochemical, genetic and genomic knowledge in a structured manner. Such reconstructions are essential to bottom-up systems biology analyses and enable mechanistic investigations of the genotype-phenotype relationship.

Several global human metabolic reconstructions have been generated, as well as a number of cell-type specific reconstructions. Of the global reconstructions, Recon 1 is probably the most widely used. To make the most of the various reconstructions and to incorporate newly developed metabolic models and data - without duplication efforts - a large group of researchers, including former NBIC PhD student Miranda Stobbe, decided to pool resources and generate a community-driven consensus human metabolic reconstruction using available sources. This has resulted in Recon 2, the most comprehensive human metabolism resource to date. Recon 2 is publicly available at:

Thiele I, Swainston N, et al.
A community-driven global reconstruction of human metabolism
Nature Biotechnology, advanced online publication 3 March 2013, doi:10.1038/nbt.2488