Bioinformatics for Metabolomics and Fluxomics

General info

Date from - to

01 Jan 2005 - 01 Jul 2010

Project leader(s)

Beek, van J.H.G.M. (Hans) Dr.

Participant(s)

Ridder, de Dick Dr. ir.

Ham, van Roeland Dr.

Abstract

Now that several genomes have been sequenced, functional genomics is getting more attention. Cell function and pathology are directly reflected in metabolite levels and fluxes in metabolic pathways. Large-scale parallel measurements of metabolites and their intracellular levels are captured under the term 'metabolomics' and large-scale quantitation of metabolic fluxes is termed 'fluxomics'. This project develops bioinformatics methods and tools for these new scientific fields.

Link to the end report of this project

Publications

• Metabolic pathway alignment (M-Pal) reveals diversity and alternatives in conserved networks
• Robust modelling, measurement and analysis of human and animal metabolic systems
• Automated procedure for candidate compound selection in GC-MS metabolomics based on prediction of Kovats retention index
• M-PAS: a comprehensive and flexible metabolic pathway alignment and scoring method
• Metabolic pathway alignment between species using a comprehensive and flexible similarity measure