Biomathematics in mass spectrometry based proteomics for identification and modeling of protein networks

General info

Date from - to

01 Nov 2006 - 31 Mar 2010

Project leader(s)

van Schuppen, Jan H. Prof. dr.

Participant(s)

Grosveld, Frank G. Prof. dr.

Abstract

Cellular functions are controlled by regulatory pathways and networks of transcription factors. These pathways and networks are mapped in studies on the regulation of the genome. In international collaborations, the regulation of genome function is addressed at a higher level: genetic regulatory nodes are mapped, as are networks that control the activity of embryonic stem cells, and the process of differentiation to specific cell types. Such studies rely heavily on (bio)informatics and mathematics. This project will focus on the mathematics to analyze and model the genetic circuitry that controls the formation of the blood system.