A superficial analysis?
25 Oct 2011
The interactions at the interface between the biomaterial used in a medical device, such as stents or implants, and surrounding tissue cells are crucial in determining the body's response to the device. To counter potential complications, the surface of the implant is treated with specific coatings or modified using physical techniques like 'sanding'. Although effective, these techniques provide little control of surface characteristics. Such control is offered by micro- and nanotechnologies. However, determining the distinct surface characteristics to elicit a wanted response remains a big challenge. In a PNAS publication, a group of tissue engineers and bioinformaticians, including NBIC-faculty member Marcel Reinders, describe how they constructed a library of more than 2,000 distinct, randomly designed surface topographies and how such libraries can help to unravel the still elusive interplay between cells and biomaterial surfaces.
Unadkat HV, Hulsman M, Cornelissen K, Papenburg BJ, Truckenmüller RK, Post GF, Uetz M, Reinders MJ, Stamatialis D, van Blitterswijk CA, de Boer J
"An algorithm-based topographical biomaterials library to instruct cell fate"
PNAS 2011 Oct 4; 108(40):16565-70