Projects

Development of generic integration methodology towards a life-sciences problem-solving environment by modelling of data and knowledge

1 Apr 2005-  1 Dec 2009 

This project develops a problem-solving environment for computational life-sciences research. Such an environment allows the e-bioscientist to do comp…

Exploiting structural genomics information to corporate protein flexibility in drug design

1 Jan 2005-  1 Oct 2009 

Structural bioinformatics allows, in principle, the design of small molecules, such as potential pharmaceutical drugs, that bind specifically and tigh…

Integrative bioinformatics with data model enabled data analysis: test case industrial microorganisms

1 Jan 2005-  1 Nov 2009 

Microorganisms are widely used as cell factories. To improving these factories, to generate new products or better performance, these factories must b…

MCSIS heterogeneous data handling

1 Sep 2007-  1 Sep 2011 

The MCSIS (Molecular Class Specific Information System) technology deals with heterogeneous data that are available for G protein-coupled receptors, a…

Phenotyping clustering of multi-factorial diseases

5 Dec 2005-  1 May 2010 

Different people react differently to drugs: this simple fact is a major challenge for drug design. Biology is an integrated system of genetic, protei…

Prediction of gene function and regulation

1 Nov 2005-  1 Jan 2010 

To predict the function and regulation of genes, evidence from various data sources has to be pieced together. The challenge is to do this on a genome…

Protein knowledge building through comparative genomics and data integration

1 Jan 2005-  1 Dec 2011 

Currently, the function of only about 50-80% of proteins in each genome is known or predicted. This fraction can be increased by comparative genomics …

Structure validation for modelling purposes

1 Apr 2005-  1 Oct 2009 

3D-modelling is crucial for the study of proteins, but very complicated. Homology-modelling is the preferred approach, but very imperfect. Many errors…