Protein knowledge building through comparative genomics and data integration

General info

Date from - to

01 Jan 2005 - 01 Dec 2011

Project leader(s)

Dr. Peter M.A. Groenen

Participant(s)

Prof. dr. Roland J. Siezen

Prof. dr. Jack Leunissen

Prof. dr. Jaap Heringa

Prof. dr. Alexander E. Gorbalenya

Theme

Integrative bioinformatics

Abstract

Currently, the function of only about 50-80% of proteins in each genome is known or predicted. This fraction can be increased by comparative genomics and integration. In this project, we construct a repository of (the most) accurate sequence similarity information from all fully sequenced genomes. These sequence similarities form the basis of a phylogeny-based protein database. Also, enhanced methods of functional annotation based on sequence homology and non-homology methods are being developed. Finally, a data warehouse for enriched protein information, coupled with improved and robust visualization techniques, is being developed. This allows sophisticated data mining and knowledge building in the areas of biomedicine and biotechnology.