Structure validation for modelling purposes
General info
- Date from - to
- 01 Apr 2005 - 01 Oct 2009
- Project leader(s)
- Vriend, Gert Prof. dr.
Abstract
3D modelling is crucial for the study of proteins, but very complicated. Homology-modelling is the preferred, but imperfect, approach. Many errors in the details of protein structure can only be detected when structure validation tools are used in combination with experimental data. This project concentrates on the validation of structures solved either by X-ray, or NMR. The validation software will provide automatic feedback to protein structure refinement software so that re-refinement of (old) structures with modern software will be possible in cases where the experimental data is available.
Link to the end report of this project
Publications
- PDB improvement starts with data deposition
- Validation of protein structure models
- Re-refinement from deposited X-ray data can deliver improved models for most PDB entries
Highlights
To date in addition to protein identification, quantification of abundances of proteins and peptides is c...
The Netherlands Genomics Initiative (NGI) calls for proposals for their Venture Challenge Spring 201...
Tuberculosis (TB) is one of the world's major health problems. It is estimated that roughly one-third of ...
The demand for bioinformatics education aimed at life scientists, especially short focused courses, is ra...
Van Hijum, Siezen et al. resequenced L. Plantarum
On April 24 and 25, 2012 we will be organising the 7th edition of the Netherlands Bioinformatics Conferen...