Projects

A modular storage and analysis pipeline for quality control, analysis and MAGE-ML export of microarray data

13 Jun 2005 

A rate-limiting step in applying microarrays is data handling. This includes extraction of raw signal intensities, quality control, experiment annotat…

Design and analysis of genetical genomics experiments

1 Jan 2005-  1 Oct 2010 

We work on the development of mathematical models, methods, algorithms and software for modern large-scale genetics experiments. The focus is on creat…

Developing clinical predictors based on high-dimensional genomics data, pathway information and directed experimentation

1 Jan 2005-  1 Nov 2009 

In this project we develop statistical techniques that modify the gene selection strategy such that it takes particular known relationships between ge…

Experimental design, sample size determination and data analysis

1 Apr 2005- 31 Dec 2009 

This study aims to optimize the power of discovery in microarray studies, so that differentially expressed genes can be identified in a more cost effe…

Quantifying the association between multidimensional phenotypes and multidimensional genetic/genomic data

1 Sep 2005- 31 Dec 2009 

In this project bioinformatics tools are developed to (quantitatively) study the association between phenotypic variables, and genetic, genomic, or pr…

Understanding and reconstructing biological pathways

5 Apr 2005-  5 Jun 2011 

DNA microarrays are used to elucidate biological pathways. To visualize the expression data in a pathway context, the data can be linked to a pathway …

Unifying framework for data-driven pathway discovery

1 Jan 2004- 20 Sep 2009 

This project concentrates on the development of generic tools that enable the discovery of (evolutionary conserved) pathways by exploiting the various…