Systems biology of asymmetric relationships

General info

Date from - to

01 Sep 2010 - 01 Jan 2014

Project leader(s)

Huynen, Martijn A. Prof. dr.

Abstract

Aim of the project:
One of the most prevalent relationships between proteins is that in which one protein depends upon another protein but not the reverse – asymmetrical relationships. Our preliminary analyses suggest that the asymmetrical relations between proteins are reflected in genomics data, but we aim to go one step further and use genomics data to predict asymmetrical relationships between proteins.

Key objectives:

• Determine in which types of genomics data the asymmetric relations between proteins are reflected;
• Develop a method to integrate genomics data that allows prediction of asymmetric relations.

Approach:
We will start by obtaining protein-pairs with either symmetric relationships or with
asymmetric relationships. Next, we will analyse which type of genomics data provides the strongest reflection of asymmetric relationships (gene expression, phenotypic data, phylogenetic distribution data). Subsequently we will develop a classifier to integrate the various types of relevant genomics data to predict asymmetric relationships.