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HotTopics: Gene regulatory interaction networks

The field of molecular biology is facing the challenge to bridge the data-knowledge gap. Clearly, the current data deluge is not automatically leading to new biological insight. Therefore it becomes unarguably clear that computational methods will be required to piece together the biological principles that underlie these enormous amounts of data.

During this HotTopics meeting we will elaborate on the use of methods to elucidate and predict (gene) regulatory interactions from large biomolecular datasets, with special focus on recent novel biomolecular data types and ways of integrating them. Of particular interest are methods that employ a module based approach, i.e. summarization of data into modules and application of interaction inference between and within these modules.

The aim is to identify advances, issues and challenges of these methods in the context of recent developments in genomics, proteomics and metabolomics. In an open discussion we want to learn how to make the best out of these computational techniques for a better understanding of biology.

Keywords: regulatory interaction, networks, modules, high-throughput data

Programme July 12th

12:30 - 12:35 Welcome - Marc van Driel
12:35 - 13:15 Lunch
13:15 – 13:55 A scale space view on omics data
  Jeroen de Ridder, TU Delft
13:55 – 14:45 Inferring transcriptional modules from coexpression
  networks
  Perry Moerland, AMC, Amsterdam
14.45 –15.35 Computational approaches for condition-responsive
  module detection
  Gunnar Klau, CWI, Amsterdam
15.35 – 16.25 Prediction of gene regulatory interactions using flow
  cytometry, ChIP-seq and phosphoproteomics
  Theo Knijnenburg, NKI, Amsterdam
16.25 – 16.55 General discussion
16.55 – 17.00 Closing

Location

Hogeschool Domstad, Koningsbergerstraat 9, 3531 AJ Utrecht
(max. 25 participants) - Google maps
Parking a car is possible on the parking lot of the Jaarbeurs in Utrecht. Do not try to park near the building, because there is very limited space.

About HotTopics

NBIC HotTopics are a new series of NBIC meetings committed to bringing scientists together to discuss the concepts and methods on a hot topic in their research field. It should provide a platform to keep in touch with peers in the field and foster sharing of new insights, applications and collaborations. Therefore, the aim of the meeting is not to present the latest results of your own work, but rather to identify new trends and breakthroughs in the field in general.

Four scientists will give a 20 minute lecture followed by 40 minutes of discussion on the important computational concepts:

  • What does a method try to accomplish?
  • What assumptions were made?
  • How does this method compare to similar ones?
  • What are the strengths, weaknesses and pitfalls?
  • Can we apply it in other areas?
  • What are the limitations and challenges for new applications and developments?

Flip over, beamer and laptop are available.

Registration

Please register for the meeting by filling out the registration form!

Organising committee

Dr. Jeroen de Ridder - Delft University of Technology
Dr. Marc van Driel – Netherlands Bioinformatics Centre (NBIC)
(phone: +31 6 24448612 / +31 24 3613306)