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Projects

Development of generic integration methodology towards a life-sciences problem-solving environment by modelling of data and knowledge

1 Apr 2005-  1 Dec 2009 

The overall aim of this project is to develop problem-solving environments (PSEs) for computational life-sciences research. For this, semantically ann…

Exploiting structural genomics information to corporate protein flexibility in drug design

1 Jan 2005-  1 Oct 2009 

Structural bioinformatics allows, in principle, the design of small molecules, such as potential pharmaceutical drugs, that bind specifically and tigh…

Integrative bioinformatics with data model enabled data analysis: test case industrial microorganisms

1 Jan 2005-  1 Nov 2009 

Microorganisms are widely used as cell factories. To improve these factories, generate new products or enhance their performance, these factories must…

MCSIS heterogeneous data handling

1 Sep 2007-  1 Sep 2011 

The MCSIS (Molecular Class Specific Information System) technology deals with heterogeneous data that are available for G protein-coupled receptors, a…

Phenotyping clustering of multi-factorial diseases

5 Dec 2005-  1 May 2010 

Different people react differently to drugs. This simple fact creates a major challenge for drug design. Biology is an integrated system of genetic, p…

Prediction of gene function and regulation

1 Nov 2005-  1 Jan 2010 

To predict the function and regulation of genes, evidence from various data sources has to be pieced together. The challenge is to do this on a genome…

Protein knowledge building through comparative genomics and data integration

1 Jan 2005-  1 Dec 2011 

Currently, the function of only about 50-80% of proteins in each genome is known or predicted. This fraction can be increased by comparative genomics …

Structure validation for modelling purposes

1 Apr 2005-  1 Oct 2009 

3D modelling is crucial for the study of proteins, but very complicated. Homology-modelling is the preferred, but imperfect, approach. Many errors in …