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Projects

A modular storage and analysis pipeline for quality control, analysis and MAGE-ML export of microarray data

13 Jun 2005-  1 Jan 2009 

A rate-limiting step in applying microarrays is data handling. This includes extraction of raw signal intensities, quality control, experiment annotat…

Design and analysis of genetical genomics experiments

1 Jan 2005-  1 Oct 2010 

This project tackles the development of mathematical models, methods, algorithms and software for modern large-scale genetics experiments. The focus i…

Developing clinical predictors based on high-dimensional genomics data, pathway information and directed experimentation

1 Jan 2005-  1 Nov 2009 

In this project we develop statistical techniques that modify the gene selection strategy such that it takes particular known relationships between …

Experimental design, sample size determination and data analysis

1 Apr 2005- 31 Dec 2009 

This project aims to optimize the power of discovery in microarray studies, so that differentially expressed genes can be identified in a more cost ef…

Quantifying the association between multidimensional phenotypes and multidimensional genetic/genomic data

1 Sep 2005- 31 Dec 2009 

In this project bioinformatics tools are developed to (quantitatively) study the association between phenotypic variables, and genetic, genomic, or pr…

Understanding and reconstructing biological pathways

5 Apr 2005-  5 Jun 2011 

DNA microarrays are used to elucidate biological pathways. To visualize the expression data in a pathway context, the data can be linked to a pathway …

Unifying framework for data-driven pathway discovery

1 Jan 2004- 20 Sep 2009 

This project concentrates on the development of generic tools that enable the discovery of (evolutionary conserved) pathways by exploiting the various…