Print this page

Sequence-based bioinformatics

The analysis of DNA, RNA and protein sequences is traditionally one of the major application areas for bioinformatics tools and methods. Such analyses require methods for sequence alignment, phylogenetics reconstruction (for functional analysis), elucidation of genome structures, functional analysis of non-coding DNA, expression analysis, and determining genetic variation. With the arrival of the new generation high-throughput sequencers, new research challenges as well as opportunities have entered the arena. Not to mention the quantum leap in generated data volumes. All this, combined with the limited availability or complete lack of other experimental data, creates a pressing need for novel bioinformatics methods that can infer biological functions and processes directly from sequence-level information.

Programme leader: Roeland van Ham, KeyGene